Diagnosis, prognosis and treatment of canine cutaneous and subcutaneous mast cell tumors

Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field. It represents the third most common tumor subtype, and is the most common malignant skin tumor in dogs, corresponding to 11% of skin cancer cases. The objective of this critical review was to present the report of the 2nd Consensus meeting on the Diagnosis, Prognosis, and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors, which was organized by the Brazilian Association of Veterinary Oncology (ABROVET) in August 2021. The most recent information on cutaneous and subcutaneous mast cell tumors in dogs is presented and discussed

The expansion of exotic Chinook salmon (Oncorhynchus tshawytscha) in the extreme south of Patagonia: an environmental DNA approach

The ability to detect species at low densities, greatly improves the success of management action on alien invasive species and decreases their possible impact on ecosystems. In the last two decades, exotic Chinook salmon (Oncorhynchus tshawytscha) have established populations in both Pacific and Atlantic river basins of Patagonia. The last established populations have been reported in the extreme south of Patagonia, on the island of Tierra del Fuego (TDF). The relatively recent appearance of Chinook salmon in TDF and the great phenotypic plasticity of this species, make it necessary to study their distribution and expansion as soon as possible, since they have the potential to negatively impact on native ecosystems. With the objective of knowing the current distribution status of exotic Chinook salmon in TDF, we optimized and implemented a detection method based on environmental DNA (eDNA). First, we designed Chinook salmon-specific primers, with no cross-amplification, using DNA from other species that are living at the same environment. Second, we validated the primers in situ by detecting Chinook salmon DNA from natural environments at the same time that we performed a conventional survey using an electrofishing survey method. Finally, we collected water samples from 10 river basins and one estuary within TDF and one river basin from Isla de los Estados (IE) and performed single-species real-time PCR assays. We were able to detect Chinook salmon DNA from 5 basins and from the estuary in TDF. These eDNA-based results allowed us to confirm the expansion of exotic Chinook salmon since they were first reported in TDF.Fil: Nardi, Cristina Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentina. Universidad Nacional de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Instituto de Ciencias Polares, Ambientales y Recursos Naturales; ArgentinaFil: Fernandez, Daniel Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentina. Universidad Nacional de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Instituto de Ciencias Polares, Ambientales y Recursos Naturales; ArgentinaFil: Vanella, Fabián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Chalde, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentin

Brazilian consensus for the diagnosis, treatment and prognosis of cutaneous mast cell tumors in dogs

Mast cell tumors represent the most common malignant skin tumor in the dog. This review outlines the incidence, etiology and clinical signs of mast cell tumors. Diagnostic tests, staging and treatments are also discussed. This study was performed by the Veterinary Oncology and Pathology of UNESP, Jaboticabal and the Service of Pathology Veterinary, of UNESP-Botucatu with the support of the Brazilian Association of Veterinary Oncology and the Brazilian Association of Veterinary Pathology

Avaliaçao de um sistema hipermídia para o ensino de Física Moderna

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UMA PROPOSTA DE SOFTWARE HIPERMÍDIA PARA O ENSINO DE FÍSICA MODERNA E CONTEMPORÂNEA*

Relata-se aqui o desenvolvimento de um software educacional, parte integrante de uma pesquisa emandamento na qual se estuda a inserção de tópicos de Física Moderna e Contemporânea (FMC) noEnsino Médio. O desenvolvimento do software é fundamentado principalmente em estudos sobre ahipermídia educativa e em princípios de ensino e aprendizagem derivados do construtivismo cognitivistade Ausubel. São mostrados os conceitos de FMC selecionados para compor o software, ostextos utilizados e alguns exemplos de inter-relações entre os mesmos, visando estabelecer oslinks do hipertexto

Charmed hadron production in high-energy nuclear collisions

We present a new model for the description of heavy-flavor hadronization in high-energy nuclear (and possibly hadronic) collisions, where the process takes place not in the vacuum, but in the presence of other color charges. We explore its effect on the charmed hadron yields and kinematic distributions once the latter is applied at the end of transport calculations used to simulate the propagation of heavy quarks in the deconfined fireball produced in nuclear collisions. The model is based on the formation of color-singlet clusters through the recombination of charm quarks with light antiquarks or diquarks from the same fluid cell. This local mechanism of color neutralization leads to a strong space-momentum correlation, which provides a substantial enhancement of charmed baryon production -- with respect to expectations based on $e^+e^-$ collisions -- and of the collective flow of all charmed hadrons. We also discuss the similarities between our model and recently developed mechanisms implemented in QCD event generators to simulate medium corrections to hadronization in the presence of other nearby color charges.Comment: 6 pages, proceedings of ICHEP-2022. arXiv admin note: substantial text overlap with arXiv:2209.0423

Heavy-flavor transport and hadronization in pp collisions

Recent experimental results on the Lambda_c/D^0 ratio in proton-proton collisions have revealed a significant enhancement compared to expectations based on universal fragmentation fractions/functions across different colliding systems, from e+e- to pp. This unexpected enhancement has sparked speculation about the potential effects of a deconfined medium impacting hadronization, previously considered exclusive to heavy-ion collisions. In this study, we propose a novel approach that assumes the formation of a small, deconfined, and expanding fireball even in pp collisions, where charm quarks can undergo rescattering and hadronization. We make use of the same in-medium hadronization mechanism developed for heavy-ion collisions, which involves local color-neutralization through recombination of charm quarks with nearby opposite color charges from the background fireball. Our model incorporates the presence of diquark excitations in the hot medium, which promotes the formation of charmed baryons. Moreover, the recombination process, involving closely aligned partons from the same fluid cell, effectively transfers the collective flow of the system to the final charmed hadrons. We show that this framework can qualitatively reproduce the observed experimental findings in heavy-flavor particle-yield ratios, $p_T$-spectra and elliptic-flow coefficients. Our results provide new, complementary supporting evidence that the collective phenomena observed in small systems naturally have the same origin as those observed in heavy-ion collision

RoboCup Soccer Leagues

RoboCup was created in 1996 by a group of Japanese, American, and European Artificial Intelligence and Robotics researchers with a formidable, visionary long-term challenge: “By 2050 a team of robot soccer players will beat the human World Cup champion team.” At that time, in the mid 90s, when there were very few effective mobile robots and the Honda P2 humanoid robot was presented to a stunning public for the first time also in 1996, the RoboCup challenge, set as an adversarial game between teams of autonomous robots, was fascinating and exciting. RoboCup enthusiastically and concretely introduced three robot soccer leagues, namely “Simulation,” “Small-Size,” and “Middle-Size,” as we explain below, and organized its first competitions at IJCAI’97 in Nagoya with a surprising number of 100 participants [RC97]. It was the beginning of what became a continously growing research community. RoboCup established itself as a structured organization (the RoboCup Federation www.RoboCup.org). RoboCup fosters annual competition events, where the scientific challenges faced by the researchers are addressed in a setting that is attractive also to the general public. and the RoboCup events are the ones most popular and attended in the research fields of AI and Robotics.RoboCup further includes a technical symposium with contributions relevant to the RoboCup competitions and beyond to the general AI and robotics